Friday, November 4, 2016

263rd post


"and he (the drill sergeant) yelled at us "don't you dirt bags know how to 

make a bunk, do it again and hurry up you scumbags because might miss 


And there was another thing I did not like...." Inspections. Sometimes the 

drill sergeant held the inspections and that was the worse. He nit picked 

everything while we stood at attention,"Hold your head up, chin and chest 

out.  You look like a girl. What the hell is wrong with you, you scum bucket?"

He checked the appearance of our starched olive drab uniforms and he 

was not happy when something wasn't right. He checked our footlockers 

to see if it duplicated the diagram like I told you before. He also inspected 

the barracks for its spit shined floor and the rest of the barracks including 

the toilets. I was kind of leary at first at trying to poop, the commodes just 

opposite each and staring in to the face of another trainee trying to poop.

And if you had constipation or diarrhea.... 



"Why would God allow a child to die when he could take a person, like

me, who has already lived his life on earth?"
Forrest Caricofe

Google search: About 6,370,000 results (1.18 seconds) 

No results found for "Why would God allow a child to die when he could 

take a person, like me, who has already lived his life on earth?"


Special to The Washington Post

By Dan Hurley

Could polio drugs treat children with a mysterious paralyzing disease?

November 4, 2016 

Superbug Gene

"Researchers developing drugs against polio and other polio-like viruses say 

those drugs could potentially be effective against a mysterious, polio-like 

condition called acute flaccid myelitis (AFM).

The Centers for Disease Control and Prevention has confirmed 89 cases of 

the paralyzing disease in the United States through September. A 6-year-old 

boy suspected of having AFM died in Seattle on Sunday, the first death 

believed to be caused by the disease.

One of the drugs in development, pocapavir, was used briefly on a few 

patients during a 2014 outbreak of AFM under a compassionate-use 

exception that allows extremely sick patients to be given unapproved drugs 

without the usual kinds of placebo-controlled trials required by the Food 

and Drug Administration.

“There were a couple of kids who got pocapavir in the Colorado outbreaks,” 

said Benjamin Greenberg, a neurologist who has treated children with AFM 

at the University of Texas Southwestern in Dallas. “It had relatively weak but 

measurable impact on viral replication. A larger study would definitely be 

warranted. We’ll take anything we can get.”

Although the CDC says no cause has been conclusively linked to AFM, many 

researchers suspect a family of viruses known as enteroviruses. A growing 

line of evidence had suggested that the condition may be a rare but serious 

complication of infection with enterovirus D68 — which is in the same viral 

family as the polio virus — the case for D68 has weakened, because no 

similar outbreak of respiratory illnesses associated with D68 or any other 

enterovirus has been seen in the United States, leaving researchers 

desperately searching for answers. (Both children affected by AFM in 

Canada, however, tested positive for exposure to D68.)

“I have been studying enteroviruses for 40 years now,” said John Modlin, 

deputy director of the polio eradication program at the Bill and Melinda 

Gates Foundation. “If I had a child with acute flaccid myelitis, I would be 

on the phone in a second to the companies making these drugs.”

None of the drugs is approved by the Food and Drug Administration. Even 

pocapavir is currently unavailable on any basis because the FDA has 

required the small company studying it to submit a New Drug Application 

before it would consider allowing the drug to be offered on a compassionate-

use basis again, said Marc Collett, president of the company, ViroDefense 

Inc. of Chevy Chase, Md.

Even if the drugs could reach patients, Dr. Modlin said, they would only be 

effective — if they work at all — in the few days or hours when the condition 

first strikes.

Despite those considerable drawbacks, not to mention the fact that no 

enterovirus has yet been proved to cause AFM, the CDC official in charge of 

its polio research says he understands the logic in trying to make the drugs 

available on a compassionate-use basis.

“It is true there are a number of drugs that have been through safety trials,” 

said Steve Oberste, chief of the CDC’s Polio and Picornavirus Laboratory 

Branch. “Some have been through phase 2 efficacy trials, and some have 

previously been used in other compassionate-use cases. But in those cases, 

at least we knew there was an infectious agent, we knew what it was, so it 

was easier to justify. Still, I can certainly understand why someone might 

say, well, this drug is proven safe, what have I got to lose?”

Marijo De Guzman, whose son Daniel died Sunday following a tentative 

diagnosis of AFM, said that if her child had been offered the opportunity 

to receive one of the experimental drugs, “I would have said, let’s try it, 

whatever we can do to try to save my son.”

One of the drugs, pleconaril, was tested in newborns for the treatment of sepsis 

caused by enterovirus. In the study published in March, the drug was found 

to cut the risk of death from 42 percent in the placebo group to 23 percent in 

the group that received the drug. It is now under development as a treatment 

for enterovirus sepsis.

Pleconaril was rejected a decade ago by the FDA as a treatment for 

rhinovirus, the cause of the common cold. Despite evidence from randomized 

clinical trials that it shortened the duration and severity of the cold, it 

appeared to increase the possibility that women taking birth control pills 

would get pregnant. Because the common cold is relatively benign and 

self-limiting, the side effect was considered too much to justify approval.

The other two drugs, pocapavir and V7404, are under study by ViroDefense, 

a company that consists of Mr. Collett and two other employees. With funding 

or assistance from the CDC, World Health Organization, the Gates Foundation, 

Rotary International and the FDA, they are developing the drugs as possible 

treatments for polio and other enterovirus infections.

Although vaccines against polio were first developed in the 1950s and have 

remained the backbone of eradication efforts, these drugs are being 

developed for people with immune deficiencies who can excrete the 

modified version of the virus contained in the vaccine for months following 

inoculation. Once excreted, the virus can continue to mutate in the 

environment and regain enough strength to infect other, non-vaccinated 


By stopping replication of the virus in those people with immune deficiencies, 

therefore, the drugs are seen as a necessary final nail to shut the coffin on 

polio forever. But the drugs also look to be effective against other non-polio 

enteroviruses, which can cause sepsis in newborns and brain inflammation 

in children or adults as well as, possibly, AFM. Even Type 1 diabetes has 

been linked in many studies to exposure to enteroviruses.

“We’re contemplating a combination product with the two compounds that 

would have broad spectrum, high potency,” said Mr. Collett, a molecular 


Like the drugs used to control HIV infection, V7404 is a protease inhibitor, 

which prevents an enterovirus from replicating inside a cell. Pocapavir, on 

the other hand, is a capsid inhibitor, blocking formation of the shell that 

houses the virus’s nucleic acid.

“We do get compassionate-use request periodically,” Mr. Collett said. 

“We currently are allowed to do it only for patients outside the United States.

” The company hopes to have a New Drug Application ready to submit to 

the FDA by early in 2017, he said. Only then would the FDA consider allowing 

the drug to be offered again on a compassionate-use basis.

If AFM is caused by an enterovirus, he said, “I think the drugs will be useful. 

We’re treating a polio case right now [in Argentina]. Pocapavir has been in 

a phase 1 study involving 114 patients, a phase 2 study, and was given on a 

compassionate-use basis to 23 infants, children and adults in the U.S. No 

adverse events have been seen above and beyond the control-study levels. 

We’re pretty hopeful. I don’t think anyone would doubt the urgency or the 

need. But then there’s the reality of clinical development. Trying to raise 

the money to lead to the drug getting to these very sick patients remains a 

significant challenge.”

Current treatments for AFM include the use of intravenous gamma globulin — 

antibodies obtained from the blood serum of many people and given in an 

attempt to boost a patient’s ability to fight infections. Prozac has also been 

used, based on studies in animals suggesting it might have an effect. None 

of the therapies has yet been shown to have a significant benefit on patients.

Despite the uncertainties, Dr. Modlin at the Gates Foundation said, “There 

is a far greater likelihood that these drugs would work better than existing 

therapies for AFM.”"

Melinda Gates - Chevy Chase - United States - North America - U.S. Food and 

Drug Administration - Centers for Disease Control and Prevention - Bill and

Melinda Gates Foundation - U.S. Department of Health and Human Services - 

United States government



Excerpt from full article:

"Iraqi troops begin to liberate eastern Mosul neighborhoods

Mosul, Iraq.... Buoyed after breaching the city limits of Mosul for the first time 

two years, Iraqi troops are engaged in hard-fought battles with militants to 

liberate the easternmost neighborhoods of the ISIS stronghold."


Bill watching me listening to the TV (5:10 AM 11/4/2016 EDT).

A Cleveland Indians' fan knocked a Chicago Cubs' fan out cold.


It's just a game and you should have fun playing it.


BBC News

BBC Poll of Polls

Today                  Nov 4         Clinton 45%      Trump 45%

Yesterday            Nov 3        Clinton  48%      Trump 46 %

Last updated     November 4

Election day      November 8

Four days and counting.


I suspect now of what I had said before. Both Presidential candidates have

assembled a team of lawyers, because of the closeness of the polls, to 

contest the vote after the voting on November 8.

Headline News

Poll: Hillary Has 'Historic' 30-Pt Lead Among Fla. Hispanics

Trump: DOJ Protecting Hillary on Email Probe

Reuters Poll: Hillary Still Has 90% Chance of Winning

NBC's Pete Williams: 'There Really Isn't' a Foundation Probe

Eric Trump on David Duke: 'The Guy Does Deserve a Bullet'

WSJ/NBC Poll: Georgia a Dead Heat

Jason Chaffetz: 'I Will Never, Ever Vote for Hillary Clinton'

Report: FBI an Anti-Hillary 'Trumplandia'

Trump: Clinton Shouldn't Be Running After Foundation News

Pollster Zogby: Anything Possible Now in Wild Election

Fox Moves More States in Trump's Direction

Poll: Trump Pulls Into Tie With Clinton in NH

Larry Kudlow: Hillary's Senior Staff 'Absolutely' Jail Bound

McCaul: Clinton's Email Server Use Amounted to 'Treason'

GOP Call for Statewide Pa. Poll Watchers Is Denied

Melania Trump Speaks Out Against Online Bullying

Bill Gross: Trump Presidency Would Be 'Negative' for Bonds

Trump Not Planning Huge Election Party

New Trump Ad Ties Clinton With 'Pervert' Weiner

Poll: US Citizens in Israel Support Trump By 5 Points

Breaking News at 

Washington Post
Planning to write in Paul Ryan or Bernie Sanders?

"In an election year with two historically unpopular nominees, write-in 

candidates can be enticing to undecided voters who can't find someone to 

get behind, or who are searching for a way to voice their disappointment.

In the ABC News/Washington Post tracking poll for example, Mrs Clinton 

was ahead of Donald Trump by 12 points on 23 October, but that lead had 

narrowed to one point a week later.

Enthusiasm for Mrs Clinton had slipped slightly in that poll, with the number 

of her supporters who said they were very enthusiastic about her down 

from 51% to 47%.

Polls do tend to tighten as election day approaches anyway, but at the 

moment it's unclear what if any effect news of the FBI inquiry will have.

In a CBS poll of 13 battleground states, 52% of voters said they expected the 

emails to contain "more of what we already know" and most of those who 

said they were less likely to vote for Mrs Clinton were Republicans."


"Presidential candidates and other politicians of today are not the only ones 

with skeletons in their closets, past Presidents and other politicians have had

a lot of things to hide from public view."
Forrest Caricofe

Google search: "view" (and any subsequent words) was ignored because we 

limit queries to 32 words. 

Your search - "Presidential candidates and other politicians of today are not 

the only ones with skeletons ... - did not match any documents.


Some things you might not know of past US Presidents.

Credit Bendon, Ashland, Ohio 44085

"The first President was George Washington - he is called "The Father of 

his Country," As a general he helped win the Revolutionary War. His face 

is on the one dollar bill and the the quarter. Our nation's Capital, Washington

D. C.  is named after him.

The second President was John Adams - Father of John Quincy Adams the 6th 

President. He built up the US Navy and is called the "Father of the Navy."

He was one of the signers of the Declaration of Independence which was adopted 

July 4, 1776 and he died exaclty 50 years later on Independence Day - July 4, 1826.

The third President was Thomas Jefferson - He wrote most of the Declaration of 


He was also a spy risking death to steal rice grains from Italy to bring back to the 

United States.

His face is on the nickel and the two-dollar bill. 

He also sent Lewis and Clark on an expedition from Missouri to Oregon.

He died on the same day as John Adams - July 4, 1826.

The fourth President was James Madison - He was the shortest President at 5 feet 6 

inches tall. He's face is on the $5,000 bill which is no longer used.

The fifth President was James Monroe - He set forth the Monroe Doctrine, which 

said that no European countries could try to colonize land in the Americas.

The sixth President was John Quincy Adams - He was the son of John Adams, 

the 2nd President. As a lawyer he argued for African slaves who rebelled 

aboard a Spanish ship, called La Amistad. He argued an won - declaring that 

the Africans had a right to freedom.

He was the first President to be photographed in 1848.

The seventh President was Andrew Jackson - General Andrew Jackson was 

called "Old Hickory" because of his toughness in the War of 1812 and the

Revolutionary War and the only President to serve in both.

His face is on the 20-dollar bill.

The eight President was Martin Van Buren - He was the only President who 

had to learn English later in life. He grew up speaking Dutch.

The ninth President was William Henry Harrison - He was the grandfather of 

Benjamin Harrison the 23rd President. He died in office of pneumonia and 

served the shortest time - only one month.

The tenth President was John Tyler - He was the first President to get married

while in office."


Weather for Smithville, Ohio

Today                      PARTLY_CLOUDY       54° 36°

Sat                           SUNNY                            62° 41°

Sun                          SUNNY                            64° 38°

Mon                         PARTLY_CLOUDY       66° 41°

The Weather Channel - Weather Underground - AccuWeather

Just went back out to the garage (5:37 AM 11/4/2016 EDT) to make my second 

and last pot of coffee. I also fixed and am eating now my usual smoked oyster

sandwich, with 100% whole wheat and real creamery butter, which is always 

pleasing to my palate. It rained sometime during the night while I was sleeping.

It did not rain all day yesterday that was forecasted and it didn't matter because

I was going to work in the rain anyway.

I attempted to burn the brush in the fire pit which included pine limbs, wire

grass, sunflowers, tree branches from the trees on our property and other

unwanted products of nature that were dried out. I had the water hose ready

just in the fire got out of hand, but it was not necessary because the burn

percentage was about 25%. I knew that the pile of discarded plant life was 

wet at the bottom because of the rain that we had, but I'll just keep trying

because I know the leftovers will be a lot of good soil.

I ran out of grass seed when seeding the bare spots in the yard.

I later went down to ACE Hardware and purchased two bags of Tall Fiscus Grass

Seed. I hope that I'll be able to finish that job today.

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I like friendly people of all races and cultures.