CONTINUED FROM YESTERDAY....
"and he (the drill sergeant) yelled at us "don't you dirt bags know how to
make a bunk, do it again and hurry up you scumbags because might miss
breakfast."
And there was another thing I did not like...." Inspections. Sometimes the
drill sergeant held the inspections and that was the worse. He nit picked
everything while we stood at attention,"Hold your head up, chin and chest
out. You look like a girl. What the hell is wrong with you, you scum bucket?"
He checked the appearance of our starched olive drab uniforms and he
was not happy when something wasn't right. He checked our footlockers
to see if it duplicated the diagram like I told you before. He also inspected
the barracks for its spit shined floor and the rest of the barracks including
the toilets. I was kind of leary at first at trying to poop, the commodes just
opposite each and staring in to the face of another trainee trying to poop.
And if you had constipation or diarrhea....
TO BE CONTINUED....
QUOTE (S) FOR THIS POST
"Why would God allow a child to die when he could take a person, like
me, who has already lived his life on earth?"
Forrest Caricofe
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take a person, like me, who has already lived his life on earth?"
HEALTH
Special to The Washington Post
By Dan Hurley
Could polio drugs treat children with a mysterious paralyzing disease?
November 4, 2016
Superbug Gene
"Researchers developing drugs against polio and other polio-like viruses say
those drugs could potentially be effective against a mysterious, polio-like
condition called acute flaccid myelitis (AFM).
The Centers for Disease Control and Prevention has confirmed 89 cases of
the paralyzing disease in the United States through September. A 6-year-old
boy suspected of having AFM died in Seattle on Sunday, the first death
believed to be caused by the disease.
One of the drugs in development, pocapavir, was used briefly on a few
patients during a 2014 outbreak of AFM under a compassionate-use
exception that allows extremely sick patients to be given unapproved drugs
without the usual kinds of placebo-controlled trials required by the Food
and Drug Administration.
“There were a couple of kids who got pocapavir in the Colorado outbreaks,”
said Benjamin Greenberg, a neurologist who has treated children with AFM
at the University of Texas Southwestern in Dallas. “It had relatively weak but
measurable impact on viral replication. A larger study would definitely be
warranted. We’ll take anything we can get.”
Although the CDC says no cause has been conclusively linked to AFM, many
researchers suspect a family of viruses known as enteroviruses. A growing
line of evidence had suggested that the condition may be a rare but serious
complication of infection with enterovirus D68 — which is in the same viral
family as the polio virus — the case for D68 has weakened, because no
similar outbreak of respiratory illnesses associated with D68 or any other
enterovirus has been seen in the United States, leaving researchers
desperately searching for answers. (Both children affected by AFM in
Canada, however, tested positive for exposure to D68.)
“I have been studying enteroviruses for 40 years now,” said John Modlin,
deputy director of the polio eradication program at the Bill and Melinda
Gates Foundation. “If I had a child with acute flaccid myelitis, I would be
on the phone in a second to the companies making these drugs.”
None of the drugs is approved by the Food and Drug Administration. Even
pocapavir is currently unavailable on any basis because the FDA has
required the small company studying it to submit a New Drug Application
before it would consider allowing the drug to be offered on a compassionate-
use basis again, said Marc Collett, president of the company, ViroDefense
Inc. of Chevy Chase, Md.
Even if the drugs could reach patients, Dr. Modlin said, they would only be
effective — if they work at all — in the few days or hours when the condition
first strikes.
Despite those considerable drawbacks, not to mention the fact that no
enterovirus has yet been proved to cause AFM, the CDC official in charge of
its polio research says he understands the logic in trying to make the drugs
available on a compassionate-use basis.
“It is true there are a number of drugs that have been through safety trials,”
said Steve Oberste, chief of the CDC’s Polio and Picornavirus Laboratory
Branch. “Some have been through phase 2 efficacy trials, and some have
previously been used in other compassionate-use cases. But in those cases,
at least we knew there was an infectious agent, we knew what it was, so it
was easier to justify. Still, I can certainly understand why someone might
say, well, this drug is proven safe, what have I got to lose?”
Marijo De Guzman, whose son Daniel died Sunday following a tentative
diagnosis of AFM, said that if her child had been offered the opportunity
to receive one of the experimental drugs, “I would have said, let’s try it,
whatever we can do to try to save my son.”
One of the drugs, pleconaril, was tested in newborns for the treatment of sepsis
caused by enterovirus. In the study published in March, the drug was found
to cut the risk of death from 42 percent in the placebo group to 23 percent in
the group that received the drug. It is now under development as a treatment
for enterovirus sepsis.
Pleconaril was rejected a decade ago by the FDA as a treatment for
rhinovirus, the cause of the common cold. Despite evidence from randomized
clinical trials that it shortened the duration and severity of the cold, it
appeared to increase the possibility that women taking birth control pills
would get pregnant. Because the common cold is relatively benign and
self-limiting, the side effect was considered too much to justify approval.
The other two drugs, pocapavir and V7404, are under study by ViroDefense,
a company that consists of Mr. Collett and two other employees. With funding
or assistance from the CDC, World Health Organization, the Gates Foundation,
Rotary International and the FDA, they are developing the drugs as possible
treatments for polio and other enterovirus infections.
Although vaccines against polio were first developed in the 1950s and have
remained the backbone of eradication efforts, these drugs are being
developed for people with immune deficiencies who can excrete the
modified version of the virus contained in the vaccine for months following
inoculation. Once excreted, the virus can continue to mutate in the
environment and regain enough strength to infect other, non-vaccinated
people.
By stopping replication of the virus in those people with immune deficiencies,
therefore, the drugs are seen as a necessary final nail to shut the coffin on
polio forever. But the drugs also look to be effective against other non-polio
enteroviruses, which can cause sepsis in newborns and brain inflammation
in children or adults as well as, possibly, AFM. Even Type 1 diabetes has
been linked in many studies to exposure to enteroviruses.
“We’re contemplating a combination product with the two compounds that
would have broad spectrum, high potency,” said Mr. Collett, a molecular
biologist.
Like the drugs used to control HIV infection, V7404 is a protease inhibitor,
which prevents an enterovirus from replicating inside a cell. Pocapavir, on
the other hand, is a capsid inhibitor, blocking formation of the shell that
houses the virus’s nucleic acid.
“We do get compassionate-use request periodically,” Mr. Collett said.
“We currently are allowed to do it only for patients outside the United States.
” The company hopes to have a New Drug Application ready to submit to
the FDA by early in 2017, he said. Only then would the FDA consider allowing
the drug to be offered again on a compassionate-use basis.
If AFM is caused by an enterovirus, he said, “I think the drugs will be useful.
We’re treating a polio case right now [in Argentina]. Pocapavir has been in
a phase 1 study involving 114 patients, a phase 2 study, and was given on a
compassionate-use basis to 23 infants, children and adults in the U.S. No
adverse events have been seen above and beyond the control-study levels.
We’re pretty hopeful. I don’t think anyone would doubt the urgency or the
need. But then there’s the reality of clinical development. Trying to raise
the money to lead to the drug getting to these very sick patients remains a
significant challenge.”
Current treatments for AFM include the use of intravenous gamma globulin —
antibodies obtained from the blood serum of many people and given in an
attempt to boost a patient’s ability to fight infections. Prozac has also been
used, based on studies in animals suggesting it might have an effect. None
of the therapies has yet been shown to have a significant benefit on patients.
Despite the uncertainties, Dr. Modlin at the Gates Foundation said, “There
is a far greater likelihood that these drugs would work better than existing
therapies for AFM.”"
Melinda Gates - Chevy Chase - United States - North America - U.S. Food and
Drug Administration - Centers for Disease Control and Prevention - Bill and
Melinda Gates Foundation - U.S. Department of Health and Human Services -
United States government
VENGEANCE
CNN
Excerpt from full article:
"Iraqi troops begin to liberate eastern Mosul neighborhoods
Mosul, Iraq.... Buoyed after breaching the city limits of Mosul for the first time
two years, Iraqi troops are engaged in hard-fought battles with militants to
liberate the easternmost neighborhoods of the ISIS stronghold."
SPORTS
Bill watching me listening to the TV (5:10 AM 11/4/2016 EDT).
A Cleveland Indians' fan knocked a Chicago Cubs' fan out cold.
MY OPINION
It's just a game and you should have fun playing it.
US PRESIDENTIAL ELECTION
BBC News
BBC Poll of Polls
Today Nov 4 Clinton 45% Trump 45%
Yesterday Nov 3 Clinton 48% Trump 46 %
Last updated November 4
Election day November 8
Four days and counting.
MY OPINION
I suspect now of what I had said before. Both Presidential candidates have
assembled a team of lawyers, because of the closeness of the polls, to
contest the vote after the voting on November 8.
Newsmax.com
Headline News
Poll: Hillary Has 'Historic' 30-Pt Lead Among Fla. Hispanics
Trump: DOJ Protecting Hillary on Email Probe
Reuters Poll: Hillary Still Has 90% Chance of Winning
NBC's Pete Williams: 'There Really Isn't' a Foundation Probe
Eric Trump on David Duke: 'The Guy Does Deserve a Bullet'
WSJ/NBC Poll: Georgia a Dead Heat
Jason Chaffetz: 'I Will Never, Ever Vote for Hillary Clinton'
Report: FBI an Anti-Hillary 'Trumplandia'
Trump: Clinton Shouldn't Be Running After Foundation News
Pollster Zogby: Anything Possible Now in Wild Election
Fox Moves More States in Trump's Direction
Poll: Trump Pulls Into Tie With Clinton in NH
Larry Kudlow: Hillary's Senior Staff 'Absolutely' Jail Bound
McCaul: Clinton's Email Server Use Amounted to 'Treason'
GOP Call for Statewide Pa. Poll Watchers Is Denied
Melania Trump Speaks Out Against Online Bullying
Bill Gross: Trump Presidency Would Be 'Negative' for Bonds
Trump Not Planning Huge Election Party
New Trump Ad Ties Clinton With 'Pervert' Weiner
Poll: US Citizens in Israel Support Trump By 5 Points
Breaking News at Newsmax.com http://www.newsmax.com/#ixzz4P1mLl4Ly
Washington Post
Planning to write in Paul Ryan or Bernie Sanders?
"In an election year with two historically unpopular nominees, write-in
candidates can be enticing to undecided voters who can't find someone to
get behind, or who are searching for a way to voice their disappointment.
In the ABC News/Washington Post tracking poll for example, Mrs Clinton
was ahead of Donald Trump by 12 points on 23 October, but that lead had
narrowed to one point a week later.
Enthusiasm for Mrs Clinton had slipped slightly in that poll, with the number
of her supporters who said they were very enthusiastic about her down
from 51% to 47%.
Polls do tend to tighten as election day approaches anyway, but at the
moment it's unclear what if any effect news of the FBI inquiry will have.
In a CBS poll of 13 battleground states, 52% of voters said they expected the
emails to contain "more of what we already know" and most of those who
said they were less likely to vote for Mrs Clinton were Republicans."
QUOTE (S) FOR THIS POST
"Presidential candidates and other politicians of today are not the only ones
with skeletons in their closets, past Presidents and other politicians have had
a lot of things to hide from public view."
Forrest Caricofe
Google search: "view" (and any subsequent words) was ignored because we
limit queries to 32 words.
Your search - "Presidential candidates and other politicians of today are not
the only ones with skeletons ... - did not match any documents.
PAST US PRESIDENTS
Some things you might not know of past US Presidents.
Credit Bendon, Ashland, Ohio 44085
bendonpub.com
"The first President was George Washington - he is called "The Father of
his Country," As a general he helped win the Revolutionary War. His face
is on the one dollar bill and the the quarter. Our nation's Capital, Washington
D. C. is named after him.
The second President was John Adams - Father of John Quincy Adams the 6th
President. He built up the US Navy and is called the "Father of the Navy."
He was one of the signers of the Declaration of Independence which was adopted
July 4, 1776 and he died exaclty 50 years later on Independence Day - July 4, 1826.
The third President was Thomas Jefferson - He wrote most of the Declaration of
Independence.
He was also a spy risking death to steal rice grains from Italy to bring back to the
United States.
His face is on the nickel and the two-dollar bill.
He also sent Lewis and Clark on an expedition from Missouri to Oregon.
He died on the same day as John Adams - July 4, 1826.
The fourth President was James Madison - He was the shortest President at 5 feet 6
inches tall. He's face is on the $5,000 bill which is no longer used.
The fifth President was James Monroe - He set forth the Monroe Doctrine, which
said that no European countries could try to colonize land in the Americas.
The sixth President was John Quincy Adams - He was the son of John Adams,
the 2nd President. As a lawyer he argued for African slaves who rebelled
aboard a Spanish ship, called La Amistad. He argued an won - declaring that
the Africans had a right to freedom.
He was the first President to be photographed in 1848.
The seventh President was Andrew Jackson - General Andrew Jackson was
called "Old Hickory" because of his toughness in the War of 1812 and the
Revolutionary War and the only President to serve in both.
His face is on the 20-dollar bill.
The eight President was Martin Van Buren - He was the only President who
had to learn English later in life. He grew up speaking Dutch.
The ninth President was William Henry Harrison - He was the grandfather of
Benjamin Harrison the 23rd President. He died in office of pneumonia and
served the shortest time - only one month.
The tenth President was John Tyler - He was the first President to get married
while in office."
WEATHER
Weather for Smithville, Ohio
Today PARTLY_CLOUDY 54° 36°
Sat SUNNY 62° 41°
Sun SUNNY 64° 38°
Mon PARTLY_CLOUDY 66° 41°
The Weather Channel - Weather Underground - AccuWeather
Just went back out to the garage (5:37 AM 11/4/2016 EDT) to make my second
and last pot of coffee. I also fixed and am eating now my usual smoked oyster
sandwich, with 100% whole wheat and real creamery butter, which is always
pleasing to my palate. It rained sometime during the night while I was sleeping.
It did not rain all day yesterday that was forecasted and it didn't matter because
I was going to work in the rain anyway.
I attempted to burn the brush in the fire pit which included pine limbs, wire
grass, sunflowers, tree branches from the trees on our property and other
unwanted products of nature that were dried out. I had the water hose ready
just in the fire got out of hand, but it was not necessary because the burn
percentage was about 25%. I knew that the pile of discarded plant life was
wet at the bottom because of the rain that we had, but I'll just keep trying
because I know the leftovers will be a lot of good soil.
I ran out of grass seed when seeding the bare spots in the yard.
I later went down to ACE Hardware and purchased two bags of Tall Fiscus Grass
Seed. I hope that I'll be able to finish that job today.
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I like friendly people of all races and cultures.